| Cytochalasin B | |
|---|---|
|
Other names
Phomin |
|
| Identifiers | |
| CAS number | 14930-96-2 |
| Properties | |
| Molecular formula | C29H37NO5 |
| Molar mass | 479.6 g/mol |
| Solubility in water | 1.280 mg/L |
| Hazards | |
| MSDS | Cytochalasin B MSDS from Fermentek |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
|
| Infobox references | |
Cytochalasin B is a cell-permeable mycotoxin. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments. It inhibits cell movement and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of polymers.[1] Cytochalasin B inhibits glucose transport[2] and platelet aggregation. It blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.[3] It is also used in cloning through nuclear transfer. Here enucleated recipient cells are treated with Hoechst stain containing cytochalasin B. Cytochalasin B makes the walls of the oocytes smoother and makes it easy for micro-manipulation so that the zona pellucida is not so rigid and can be easily pierced by the micro-needles.
This alkaloid is isolated from a fungus, Helminthosporium dermatioideum.